Exemestane / Aromasin Khansa Chithandizo cha Anti Estrogen Steroids Kudula / Kuchulukitsa Kuzungulira
Tsatanetsatane Wachangu
Exemestane
Alias: Aromasin;Exemestan
Maonekedwe: Ufa Woyera Kapena Woyera Wamakristalo
Zogulitsa: ≥ 99%CAS:107868-30-4
Mapangidwe a maselo: C20H24O2
Kulemera kwa Maselo: 296.40
Ntchito: amagwiritsidwa ntchito pochiza khansa ya m'mawere ya metastatic.ndipo amagwiritsidwa ntchito ngati chithandizo pochiza khansa ya m'mawere oyambirira.
Mutha kuyimvanso ikutchedwa Aromasin, lomwe ndi dzina lake lodziwika bwino.Palinso mitundu ina ya exemestane, yomwe ili ndi mlingo wofanana wa mankhwalawa.
Malangizo a Mlingo
Mlingo Wachidziwitso Wachikulu Wa Khansa Yam'mawere:
25 mg pakamwa kamodzi patsiku
Ndemanga:
- Mankhwalawa ayenera kuperekedwa mukatha kudya.
Zogwiritsa:
- Chithandizo cha adjuvant kwa amayi omwe ali ndi vuto losiya kusamba omwe ali ndi khansa ya m'mawere yoyambirira ya estrogen-receptor omwe alandira zaka ziwiri kapena zitatu za tamoxifen ndipo amasinthidwa kukhala exemestane kuti amalize zaka zisanu zotsatizana za chithandizo cha mahomoni.
- Chithandizo cha khansa yapamwamba ya m'mawere mwa amayi omwe ali ndi matenda a postmenopausal omwe matenda awo apita patsogolo potsatira mankhwala a tamoxifen.
Kufotokozera
Aromasin (Exemestane acetate) ndi amodzi mwazinthu zodabwitsa zomwe palibe amene akudziwa zoyenera kuchita nazo.Ndi m'badwo wachitatu Aromatase Inhibitor (AI) monga Arimidex (Anastrozole) ndi Femera (Letrozole).
m'badwo wachitatu aromatase inhibitors, omwe amagwiritsidwa ntchito pochiza khansa ya m'mawere ya metastatic ndipo amagwiritsidwa ntchito ngati chithandizo pochiza khansa ya m'mawere oyambirira.
● Aromasin ndi imodzi mwa mankhwala amphamvu kwambiri opondereza estrogen.
● Aromasin ndi imodzi mwa mankhwala abwino kwambiri ochepetsera kununkhira kwa ma steroid.
● Aromasin ilipo kwa omanga thupi omwe amatenga anabolic steroids.
● Aromasin amadziwikanso kuti Exemestane.
● Imagwira ntchito mwa kutsekereza enzyme ya aromatase, kenako imalepheretsa kupanga kwa estrogen.
● Aromasin ndi mtundu wa .antineoplastic (hormonal) raw zipangizo.
Aromasin amagwiritsidwa ntchito kulimbana ndi khansa ya m'mawere ndikukweza testosterone m'thupi.
Exemestane imatchinga njira ya aromatisation.Choncho amachepetsa kuchuluka kwa estrogen m'thupi.Kumayambiriro kwa khansa ya m'mawere, kutenga exemestane kungathandize kuletsa khansa ya m'mawere kubwerera.Mu khansa ya m'mawere yapita patsogolo maselo a khansa amatha kukula pang'onopang'ono kapena kusiya kukula kwathunthu.
Exemestane ndi aromatase inhibitor.Izi zikutanthauza kuti imalepheretsa enzyme aromatase (yomwe imapezeka mu minofu ya thupi, khungu, chifuwa ndi mafuta), yomwe imagwiritsidwa ntchito potembenuza androgens (mahomoni opangidwa ndi adrenal glands) kukhala estrogen.Pakakhala estrogen, zotupa zomwe zimadalira hormone iyi kuti zikule zimachepa
Ubwino wa Exemestane
>>.Kumanga thupi
Steroidal Exemestane inhibitor yomwe imagwira ntchito pochepetsa kuchuluka kwa estrogen yopangidwa ndi thupi.Zimagwira ntchito pochepetsa kutembenuka kwa Testosterone kukhala estrogen ndipo pafupifupi mlingo wa kuponderezedwa kwa estrogen ndi 85%.Mankhwalawa amachepetsanso milingo ya estradiol pafupifupi 50%, komanso imakulitsa kwambiri milingo ya testosterone.
Exemestane inhibitor yomwe imagwira ntchito poletsa kaphatikizidwe ka estrogen.Ndiwothandiza pakukula kwa Testosterone ndi IGF m'thupi.Mankhwalawa ndi othandiza kwambiri pa nthawi ya post cycle therapy regime pamene wina akuyesera kubwezeretsa ma testosterone achilengedwe kuti apewe kuwonongeka kwa positi.
>>.Anti-estrogen mankhwala
Podziwika kuti ndi imodzi mwa mankhwala okwera mtengo kwambiri, Exemestane ndi imodzi mwa mankhwala otetezeka kwambiri a anti-estrogen omwe amagwiritsidwa ntchito makamaka ndi othamanga ndi omanga thupi.Mankhwala mankhwala makamaka zochizira khansa ya m'mawere.Nthawi zambiri amatchedwa Selective Estrogen Receptor Modulator (SERM), idagwiritsidwa ntchito popewa gynocomastia.
Ntchito ya Exemestane
A)Exemestane popewa khansa ya m'mawere:
Chemoprevention ya khansa ya m'mawere ndi njira yabwino yochepetsera kuchuluka kwa matendawa mwa amayi omwe ali pachiwopsezo.Othandizira oyamba omwe adawonetsa zotsatira zazikulu za chemopreventive anali SERMs tamoxifen ndi raloxifen.
Kusanthula kwatsatanetsatane kwa mayeso onse opewera a SERM kunawonetsa kuti amatha kuchepetsa kuchuluka kwa khansa ya m'mawere mwa amayi omwe ali pachiwopsezo chachikulu komanso chapakati, zomwe zimathandizidwa ndi kuchepetsedwa kwa khansa ya m'mawere ya ER-positive.
B)Exemestane ndi m'badwo wachitatu wosasinthika wa steroidal inactivator wa enzyme ya aromatase ndipo imakhala yothandiza pamankhwala onse a khansa ya m'mawere, kuphatikiza chemoprevention.
M'malo a metastatic, exemestane yafufuzidwa mozama ngati chithandizo choyamba, mzere wachiwiri, ndi mzere wowonjezera ndipo tsopano yalembedwa kuti azichiza amayi omwe ali ndi khansa ya m'mawere yomwe ili ndi mahomoni-receptor-positive omwe matenda awo apita patsogolo pambuyo pa antiestrogen. chithandizo.
Zindikirani, kusowa kokwanira kotsutsana ndi ma NSAI kumapereka mwayi wowonjezera pakutsata kwamankhwala kwa othandizira a endocrine.Komanso, kutengera zotsatira zachipatala, exemestane yokhala ndi everolimus imayimira njira yabwino yochizira matenda omwe apita patsogolo pambuyo pokumana ndi NSAI.
Exemestane nthawi zambiri imalekerera bwino, yokhala ndi zotsatira zake zofanana ndi za ma AI ena komanso kuphatikizapo zizindikiro za menopausal, arthralgia, mafupa, ndi kusintha kwa lipid metabolism.
