Dutasteride imagulitsidwa ndi mankhwala monga Avodart, Avidart, Avolve, Duagen, Dutas, Dutagen, Duprost.Pazifukwa zosadziwika, kuyesa koyambirira kwachipatala kwa dutasteride kunathetsedwa mwadzidzidzi mu 2002, kenako nkupitilira pambuyo pake.

Dutasteride ndi 5-alpha-reductase inhibitor, kutanthauza kuti imalepheretsa zochita za 5a-reducatse michere, yomwe imayambitsa 5a-kuchepetsa (kutembenuza) testosterone kukhala dihydrotestosterone (DHT) powonjezera mgwirizano wachiwiri wa hydrogen.

Dutasteride imalepheretsa ma isoforms onse a 5a-reductase, motero amalepheretsa kutembenuka kwa testosterone kukhala dihydrotestosterone.Izi zimapangitsa Dutasteride kukhala chithandizo choyenera cha Male Pattern Baldness.Inde, mukatembenuza Testosterone yocheperako kukhala Dihydrotestosterone, mumawonjezera ma testosterone mwachisawawa (kutembenuka kochepa).

Dutasteride, pa 2.5mgs / tsiku ndi pafupifupi 1.5x yogwira mtima kwambiri kuposa Finasteride pa 5mgs / tsiku, pochiza tsitsi (onse kuliletsa komanso kulikulitsa).Kuonjezera apo, Dutasteride ikhoza kugwiritsidwa ntchito bwino pa mlingo womwewo kuti athetse kukula kwa prostate, ndipo zotsatira zochepa zodziwika za Dutasteride (kachiwiri, pa mlingo womwewo) zimagwiritsidwa ntchito pochiza Acne chifukwa cha kuchuluka kwa androgens m'thupi.

Kwa steroid pogwiritsa ntchito wothamanga akuvutika ndi zotsatira zokhudzana ndi DHT, Dutasteride ikhoza kukhala yankho.Kumeta tsitsi, ziphuphu zakumaso, ndi kukula kwa prostate (mwina) zitha kuyimitsidwa kwathunthu pogwiritsa ntchito mankhwalawa.Tsoka ilo, DHT sizoyipa zonse, ndipo mutha kutaya kulimba kwa minofu (mtundu wa amorphous ngati ulipo), komanso mikhalidwe ina yomwe timakonda pakugwiritsa ntchito androgen.

Komanso ... popeza izi zimangolepheretsa kuchepa kwa 5a kwa ma androgens omwe amasinthidwa kukhala mawonekedwe a dihydro…

Dutasteride, pamodzi ndi Finasteride ndi 5-alpha-Reductase inhibitor omwe ali gulu la mankhwala omwe ali ndi anti-androgenic katundu omwe amalepheretsa kutembenuka kwa testosterone kukhala dihydrotestosterone (DHT).Ichi ndi mankhwala omwewo omwe amapezeka mu Proscar ndi Propecia ndipo amagwiritsidwa ntchito pochiza hyperplasia ndi androgenic alopecia.Chifukwa mankhwalawa amachepetsa milingo ya dihydrotestosterone (DHT) amagwiritsidwa ntchito popewa komanso kuchiza tsitsi.Amagwiritsidwa ntchito kwambiri pochiza prostate glands.